Organosulfur Compounds
Medchemexpress LLC (+)-LRH-1 modulator-1 | 99.38% | 464.66 | 1 MG
(+)-LRH-1 modulator-1 is a stereoisomer of LRH-1 modulator-1, which is a potent LRH-1 (liver receptor homolog-1) modulator/agonist. It exhibits anti-inflammatory effects in intestinal organoids by inducing the anti-inflammatory cytokine IL-10 and reducing the inflammatory cytokines IL-1b and TNFa.
- Potent LRH-1 modulator/agonist
- Demonstrates anti-inflammatory effects
- Induces IL-10 cytokine
- Reduces IL-1b and TNFa cytokines
Cayman Chemical Sulindac sulfide, Purity: ≥98%, CAS: 49627-27-2, 1 mg
An active metabolite of sulindac; inhibits COX-1 and COX-2 (IC50s = 1.9 and 1.21 µM, respectively); inhibits aldose reductase (IC50 = 279 nM), blocking NADPH-dependent reduction of glucose to sorbitol, and reducing type 2 diabetic complications; inhibits colorectal cancer growth in vitro and in vivo
Medchemexpress LLC Sirtuin modulator 1 | 2070015-26-6 | MFCD29924722 | 99.9% | 10 MG
Sirtuin modulator 1 is a small-molecule modulator of SIRT1 (a homolog of SIRT3) reported with an EC1.5 of <1 μM and described in patent WO 2010071853 A1 (Compound No. 4). Supplied as a high-purity solid for research use, it is intended for biochemical and cellular studies of sirtuin activity.
- High reported purity for assay-ready use.
- Molecular formula C31H32ClN5O2S2, molecular weight 606.20 g/mol.
- CAS number 2070015-26-6 for unambiguous identification.
- Reported EC1.5 potency of <1 μM against SIRT1.
- Available in milligram-scale quantities suitable for research.
Medchemexpress LLC Triclabendazole sulfoxide (TCBZ-SO) | 100648-13-3 | 98.8% | 375.66 | 25 MG
Triclabendazole sulfoxide (TCBZ-SO) is the main plasma metabolite of Triclabendazole. It exhibits anti-parasite effects and can inhibit the membrane transporter ABCG2/BCRP.
- Main plasma metabolite of Triclabendazole
- Exhibits anti-parasite effects
- Inhibits the membrane transporter ABCG2/BCRP
- Useful in infection disease research
- Useful in cancer disease research
- Useful in parasitic infection research
Medchemexpress LLC Kv3 modulator 2 | 2101321-76-8 | 99.9% | 379.41 g·mol⁻¹ | C21H21N3O4 | 5 MG
Kv3 modulator 2 is a small-molecule modulator of Kv3 voltage-gated potassium channels with reported analgesic activity. It is provided for laboratory research use and is characterized by a defined molecular formula and molecular weight, and high purity suitable for preclinical studies.
- High purity (99.9%).
- Available in small research quantities (example: 5 mg).
- Molecular formula C21H21N3O4; molecular weight 379.41 g·mol⁻¹.
- Reported Kv3 channel modulatory activity with analgesic effects.
- For research use only; not for human or clinical use.
Medchemexpress LLC Sirtuin modulator 3 10mg | 10mg
Sirtuin modulator 3 (compound 129) is a N-phenyl benzamide derivative acts as a sirtuin modulator[1]
Medchemexpress LLC 3-isoxazolecarboxamide, N-(2-cyclohexyl-2,3-dihydro-1,5-dimethyl-3-oxo-1H-pyrazol-4-yl)-4-methyl-5-... | 1825371-51-4 | 99.8% | 446.54 | 1 MG
Smurf1 modulator-1 (Compound 20) is a selective inhibitor for Smad ubiquitination regulatory factor 1 (Smurf1), with an IC50 of 180 nM. This product is for research use only and not sold to patients.
- Selective inhibitor for Smad ubiquiquitination regulatory factor 1 (Smurf1).
- IC50 of 180 nM.
- For research use only.
- Appearance is a white to off-white solid.
- Specific storage conditions for powder and in solvent.
- Soluble in DMSO.
Medchemexpress LLC Nourseothricin (sulfate) | 96736-11-7 | 99.9% | 1 G
Nourseothricin sulfate is a broad-spectrum antibiotic that inhibits protein biosynthesis in prokaryotic cells and destroys the outer membrane of Gram-negative bacteria. It also functions as a selective marker for *Fonsecaea pedrosoi* and is effective for a diverse range of organisms including bacteria, yeast, filamentous fungi, and plant cells.
- Broad-spectrum antibiotic
- Destroys outer membrane of Gram-negative bacteria
- Inhibits protein biosynthesis in prokaryotic cells
- Inhibits growth of eukaryotes such as fungi
- Selective marker for *Fonsecaea pedrosoi*
- Used as an elective marker for various organisms
Medchemexpress LLC Nur77 modulator 3 | 2097787-75-0 | 99.0% | 308.40 | 100 MG
Nur77 modulator 3 is a Nur77 modulator that induces Nur77 expression, inhibits hepatic stellate cells (HSCs) activation, and reduces extracellular matrix (ECM) deposition. It enhances Nur77-dependent autophagic flux and significantly inhibits the mTORC1 signaling pathway. This modulator can ameliorate HSCs activation, inflammation, and hepatic fibrosis *in vivo*.
- Induces Nur77 expression
- Inhibits hepatic stellate cells (HSCs) activation
- Reduces extracellular matrix (ECM) deposition
- Enhances Nur77-dependent autophagic flux
- Significantly inhibits the mTORC1 signaling pathway
- Ameliorates HSCs activation, inflammation, and hepatic fibrosis *in vivo*
Medchemexpress LLC YK-2168 | 2571068-74-9 | 98.1% | 315.80 | 5 MG
YK-2168 is a potent and selective CDK9 inhibitor with an IC50 of 5.9 nM. It inhibits phosphorylation of the CDK9 substrate pS2-RNA Pol II C-terminal domain. YK-2168 induces apoptosis in tumor cells, suppresses expression of CDK9-regulated genes such as MYC and Mcl1, and inhibits tumor growth in CDX mice models. It can be used for the research of cancer, such as leukemia.
- Potent and selective CDK9 inhibitor
- Induces apoptosis in tumor cells
- Suppresses expression of CDK9-regulated genes
- Inhibits tumor growth in CDX mice models
- Suitable for research in cancer, such as leukemia
Research Products International Corp 4Meth BDGalact 6 Sulf Sod 50MG
Fluorescent substrate for Morquio A Sulphatase.
- 4-Methylumbelliferone: <100PPM
Cayman Chemical Sulindac, Purity: ≥98%, CAS: 38194-50-2, 1 g
An NSAID, a COX-2 inhibitor (IC50 = 0.79 µM), and a prodrug form of sulindac sulfide; selective for COX-2 over COX-1 (IC50 = >1,000 µM); inhibits acetic acid-induced writhing in mice and reduces carrageenan-induced paw edema in rats at 100 mg/kg; reduces tumor growth in a BxPC-3 mouse xenograft model at 60 mg/kg
Medchemexpress LLC GLP-1R modulator C16 | 875005-43-9 | 98.7% | C21H26ClFN2O3 | 50 MG
GLP-1R modulator C16 is an allosteric modulator enhancing GLP-1 binding to GLP-1R via a transmembrane site (EC50 8.43 ± 3.82 μM).
- Enhances GLP-1 binding to GLP-1R.
- Acts via a transmembrane site.
- High purity of 98.7% confirmed by LCMS.
- Recommended storage conditions for powder: -20°C for 3 years, 4°C for 2 years.
- Recommended storage conditions for in solvent: -80°C for 6 months, -20°C for 1 month.
Medchemexpress LLC GPR120 modulator 2 | 1050506-87-0 | 97.1% | 387.88 | C20H18ClNO3S | 10 MG
GPR120 modulator 2 is a small-molecule research compound that modulates the free fatty acid receptor GPR120 and is intended for in vitro pharmacology and metabolic signaling studies.
- Targets the free fatty acid receptor GPR120.
- Molecular formula C20H18ClNO3S and molecular weight 387.88.
- CAS number 1050506-87-0 for unambiguous identification.
- High purity (97.1%) suitable for research applications.
- Available in small pack sizes, including 10 mg.
- Storage: powder at -20°C for long-term stability, 4°C short term; in solvent store at -80°C.
Medchemexpress LLC IL-17 modulator 3 | 2467731-88-8 | 99.51% | 579.73 | 1 ML
IL-17 modulator 3 is an IL-17 modulator that can be used for the research of inflammation, cancer, and autoimmune diseases. This product is for research use only and not sold to patients.
- Used for research of inflammation
- Used for research of cancer
- Used for research of autoimmune diseases